No scientific evidence for main antidepressants

Selective Serotonin Reuptake Inhibitor (SSRI) antidepressants are the most prescribed. It has been suggested that depression is associated with lowered serotonin concentration or activity and SSRIs are supposed to increase serotonin. However, a recent research review has found no support for the hypothesis that depression is caused by lowered serotonin activity or concentrations. The most worrying is that SSRIs may cause serious side effects and addiction. More information: https://www.nature.com/articles/s41380-022-01661-0 and https://joannamoncrieff.com/